Microglial P2X(7) receptor expression is accompanied by neuronal damage in the cerebral cortex of the APP(swe)/PS1dE9 mouse model of Alzheimer's disease

The possibility that P2X(7) receptor (P2X(7)R) expression in microglia would mediate neuronal damage via reactive oxygen species (ROS) production was examined in the APP(swe)/PS1dE9 mouse model of Alzheimer's disease (AD). P2X(7)R was predominantly expressed in CD11b-immunopositive microglia fr...

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Bibliografiske detaljer
Main Authors: Lee, Hwan Goo, Won, Sun Mi, Gwag, Byoung Joo, Lee, Yong Beom
Format: Artigo
Sprog:Inglês
Udgivet: Korean Society for Biochemistry and Molecular Biology 2011
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3041940/
https://ncbi.nlm.nih.gov/pubmed/21088470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3858/emm.2011.43.1.001
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