Localized Delivery of Interferon-β by Lactobacillus Exacerbates Experimental Colitis

BACKGROUND: There have been conflicting reports of the role of Type I interferons (IFN) in inflammatory bowel disease (IBD). Clinical trials have shown potent efficacy of systemic interferon-beta (IFN-β) in inducing remission of ulcerative colitis. Likewise, IFNAR1(−/−) mice display an increased sen...

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Bibliographic Details
Main Authors: McFarland, Adelle P., Savan, Ram, Wagage, Sagie, Addison, Augustina, Ramakrishnan, Karthika, Karwan, Megan, Duong, Tri, Young, Howard A.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3041828/
https://ncbi.nlm.nih.gov/pubmed/21365015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0016967
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