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Synthesis and Biological Screening of 5-{[(4,6-Disubstituted pyrimidine-2-yl)thio]methyl}-N-phenyl-1,3,4-thiadiazol-2-amines

A number of substituted-α,β-unsaturated carbonyl compounds (1a-i) were prepared by Claisen-Schmidt condensation of substituted acetophenone with selected araldehydes, which on cycloaddition with thiourea furnished 4,6-disubstituted pyrimidine-2-thiols (2a-i). Reaction of (2a-i) with ethyl chloroacet...

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Main Authors: Azam, M. A., Kumar, B. R. P., Shalini, S., Suresh, B., Reddy, T. K., Reddy, C. D.
格式: Artigo
語言:Inglês
出版: Medknow Publications 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3038302/
https://ncbi.nlm.nih.gov/pubmed/21394274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4103/0250-474X.45416
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