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Therapeutic strategies and mechanisms of tumorigenesis of HER2-overexpressing breast cancer
The receptor tyrosine kinase HER2 is overexpressed in approximately 25% of breast cancers. HER2 acts as a signal amplifier for its siblings, namely three different transmembrane receptors that collectively bind with 11 distinct growth factors of the EGF family. Thus, overexpression of HER2 confers a...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3038194/ https://ncbi.nlm.nih.gov/pubmed/20951604 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.critrevonc.2010.09.002 |
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