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Therapeutic strategies and mechanisms of tumorigenesis of HER2-overexpressing breast cancer

The receptor tyrosine kinase HER2 is overexpressed in approximately 25% of breast cancers. HER2 acts as a signal amplifier for its siblings, namely three different transmembrane receptors that collectively bind with 11 distinct growth factors of the EGF family. Thus, overexpression of HER2 confers a...

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Main Authors: Emde, Anna, Köstler, Wolfgang J., Yarden, Yosef
Formato: Artigo
Idioma:Inglês
Publicado: 2010
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3038194/
https://ncbi.nlm.nih.gov/pubmed/20951604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.critrevonc.2010.09.002
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