The miR-17-92 microRNA cluster regulates multiple components of the TGFβ-pathway in neuroblastoma

The miR-17-92 microRNA cluster is often activated in cancer cells, but the identity of its targets remains elusive. Using SILAC and quantitative mass spectrometry, we examined the effects of activation of the miR-17-92 cluster on global protein expression in neuroblastoma cells. Our results reveal c...

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Detalhes bibliográficos
Main Authors: Mestdagh, Pieter, Boström, Anna-Karin, Impens, Francis, Fredlund, Erik, Van Peer, Gert, De Antonellis, Pasqualino, von Stedingk, Kristoffer, Ghesquière, Bart, Schulte, Stefanie, Dews, Michael, Thomas-Tikhonenko, Andrei, Schulte, Johannes H., Zollo, Massimo, Schramm, Alexander, Gevaert, Kris, Axelson, Håkan, Speleman, Frank, Vandesompele, Jo
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3032380/
https://ncbi.nlm.nih.gov/pubmed/21145484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.11.038
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