Anti-inflammatory effects of the anticonvulsant drug levetiracetam on electrophysiological properties of astroglia are mediated via TGFβ1 regulation

BACKGROUND AND PURPOSE: The involvement of astrocytes as immune-competent players in inflammation and the pathogenesis of epilepsy and seizure-induced brain damage has recently been recognized. In clinical trials and practice, levetiracetam (LEV) has proven to be an effective antiepileptic drug (AED...

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Main Authors: Stienen, Martin N, Haghikia, Aiden, Dambach, Hannes, Thöne, Jan, Wiemann, Martin, Gold, Ralf, Chan, Andrew, Dermietzel, Rolf, Faustmann, Pedro M, Hinkerohe, Daniel, Prochnow, Nora
Format: Artigo
Language:Inglês
Published: Blackwell Publishing Ltd 2011
Subjects:
Research Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3031068/
https://ncbi.nlm.nih.gov/pubmed/20955362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.01038.x
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