Chymotrypsin C Is a Co-activator of Human Pancreatic Procarboxypeptidases A1 and A2

Human digestive carboxypeptidases CPA1, CPA2, and CPB1 are secreted by the pancreas as inactive proenzymes containing a 94–96-amino acid-long propeptide. Activation of procarboxypeptidases is initiated by proteolytic cleavage at the C-terminal end of the propeptide by trypsin. Here, we demonstrate t...

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Bibliografiske detaljer
Main Authors: Szmola, Richárd, Bence, Melinda, Carpentieri, Andrea, Szabó, András, Costello, Catherine E., Samuelson, John, Sahin-Tóth, Miklós
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2011
Fag:
Enzymology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3023477/
https://ncbi.nlm.nih.gov/pubmed/21098023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.187369
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