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Evaluation of Hepatotoxicity with Off-Label Oral-Treatment Doses of Voriconazole for Invasive Fungal Infections

The approved treatment dose of intravenous voriconazole is a weight-based dose of 4 mg/kg of body weight twice daily; the approved oral dosing is fixed at 200 mg twice daily. In our institution, patients frequently receive oral high-dose voriconazole at 4 mg/kg twice daily. It is unknown if higher d...

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Détails bibliographiques
Auteurs principaux: Gorski, Elizabeth, Esterly, John S., Postelnick, Michael, Trifilio, Steven, Fotis, Michael, Scheetz, Marc H.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology (ASM) 2011
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3019689/
https://ncbi.nlm.nih.gov/pubmed/20974867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01078-10
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