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Refinement of Under-Determined Loops of Human Prion Protein by Database-Derived Distance Constraints
Computational simulations of the conversion from the normal cellular prion (PrP(c)) to the scrapie prion (PrP(Sc)) are usually based on the structures determined by NMR because of the difficulties in crystallizing prion protein. Due to insufficient experimental restraints, a biologically critical lo...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3018887/ https://ncbi.nlm.nih.gov/pubmed/20052907 |
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