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Specificity of cholesterol and analogs to modulate BK channels points to direct sterol–channel protein interactions
The activity (Po) of large-conductance voltage/Ca(2+)-gated K(+) (BK) channels is blunted by cholesterol levels within the range found in natural membranes. We probed BK channel–forming α (cbv1) subunits in phospholipid bilayers with cholesterol and related monohydroxysterols and performed computati...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Rockefeller University Press
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3010061/ https://ncbi.nlm.nih.gov/pubmed/21149543 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201010519 |
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