Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selection

Genetic ablation of autophagy in mice leads to liver and brain degeneration accompanied by the appearance of ubiquitin (Ub) inclusions, which has been considered to support the hypothesis that ubiquitination serves as a cis-acting signal for selective autophagy. We show that tissue-specific disrupti...

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Main Authors: Riley, Brigit E., Kaiser, Stephen E., Shaler, Thomas A., Ng, Aylwin C.Y., Hara, Taichi, Hipp, Mark S., Lage, Kasper, Xavier, Ramnik J., Ryu, Kwon-Yul, Taguchi, Keiko, Yamamoto, Masayuki, Tanaka, Keiji, Mizushima, Noboru, Komatsu, Masaaki, Kopito, Ron R.
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2010
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003313/
https://ncbi.nlm.nih.gov/pubmed/21041446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201005012
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