Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selection

Genetic ablation of autophagy in mice leads to liver and brain degeneration accompanied by the appearance of ubiquitin (Ub) inclusions, which has been considered to support the hypothesis that ubiquitination serves as a cis-acting signal for selective autophagy. We show that tissue-specific disrupti...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Riley, Brigit E., Kaiser, Stephen E., Shaler, Thomas A., Ng, Aylwin C.Y., Hara, Taichi, Hipp, Mark S., Lage, Kasper, Xavier, Ramnik J., Ryu, Kwon-Yul, Taguchi, Keiko, Yamamoto, Masayuki, Tanaka, Keiji, Mizushima, Noboru, Komatsu, Masaaki, Kopito, Ron R.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: The Rockefeller University Press 2010
विषय:
Research Articles
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003313/
https://ncbi.nlm.nih.gov/pubmed/21041446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201005012
टैग : टैग जोड़ें
कोई टैग नहीं, इस रिकॉर्ड को टैग करने वाले पहले व्यक्ति बनें!

समान संसाधन