Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selection

Genetic ablation of autophagy in mice leads to liver and brain degeneration accompanied by the appearance of ubiquitin (Ub) inclusions, which has been considered to support the hypothesis that ubiquitination serves as a cis-acting signal for selective autophagy. We show that tissue-specific disrupti...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Riley, Brigit E., Kaiser, Stephen E., Shaler, Thomas A., Ng, Aylwin C.Y., Hara, Taichi, Hipp, Mark S., Lage, Kasper, Xavier, Ramnik J., Ryu, Kwon-Yul, Taguchi, Keiko, Yamamoto, Masayuki, Tanaka, Keiji, Mizushima, Noboru, Komatsu, Masaaki, Kopito, Ron R.
التنسيق: Artigo
اللغة:Inglês
منشور في: The Rockefeller University Press 2010
الموضوعات:
Research Articles
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003313/
https://ncbi.nlm.nih.gov/pubmed/21041446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201005012
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