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Cellular Reactive Oxygen Species Inhibit MPYS Induction of IFNβ
Many inflammatory diseases, as well as infections, are accompanied by elevation in cellular levels of Reactive Oxygen Species (ROS). Here we report that MPYS, a.k.a. STING, which was recently shown to mediate activation of IFNβ expression during infection, is a ROS sensor. ROS induce intermolecular...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Public Library of Science
2010
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3000824/ https://ncbi.nlm.nih.gov/pubmed/21170271 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0015142 |
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