Phenocopy – A Strategy to Qualify Chemical Compounds during Hit-to-Lead and/or Lead Optimization

A phenocopy is defined as an environmentally induced phenotype of one individual which is identical to the genotype-determined phenotype of another individual. The phenocopy phenomenon has been translated to the drug discovery process as phenotypes produced by the treatment of biological systems wit...

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Hlavní autoři: Baum, Patrick, Schmid, Ramona, Ittrich, Carina, Rust, Werner, Fundel-Clemens, Katrin, Siewert, Susanne, Baur, Martin, Mara, Lisa, Gruenbaum, Lore, Heckel, Armin, Eils, Roland, Kontermann, Roland E., Roth, Gerald J., Gantner, Florian, Schnapp, Andreas, Park, John E., Weith, Andreas, Quast, Karsten, Mennerich, Detlev
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2010
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3000806/
https://ncbi.nlm.nih.gov/pubmed/21170314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0014272
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