Suppression of stretch reflex activity after spinal or systemic treatment with AMPA receptor antagonist NGX424 in rats with developed baclofen tolerance

BACKGROUND AND PURPOSE: Baclofen (a GABA(B) receptor agonist) is the most commonly used anti-spasticity agent in clinical practice. While effective when administered spinally or systemically, the development of progressive tolerance represents a serious limitation for its long-term use. The goal of...

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Библиографические подробности
Главные авторы: Oshiro, Masakatsu, Hefferan, Michael P, Kakinohana, Osamu, Lukacova, Nadezda, Sugahara, Kazuhiro, Yaksh, Tony L, Marsala, Martin
Формат: Artigo
Язык:Inglês
Опубликовано: Blackwell Publishing Ltd 2010
Предметы:
Research Papers with Commentaries
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2998680/
https://ncbi.nlm.nih.gov/pubmed/20977450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.00954.x
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