p38 Mitogen-Activated Protein Kinase (MAPK) Increases Arginase Activity and Contributes to Endothelial Dysfunction in Corpora Cavernosa from Angiotensin-II Treated Mice

INTRODUCTION: Angiotensin II (AngII) activates p38 mitogen-activated protein kinase (MAPK) and elevates arginase activity in endothelial cells. Upregulation of arginase activity has been implicated in endothelial dysfunction by reducing NO bioavailability. However, signaling pathways activated by An...

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Main Authors: Toque, Haroldo A., Romero, Maritza J., Tostes, Rita C., Shatanawi, Alia, Chandra, Surabhi, Carneiro, Zidonia N., Inscho, Edward W., Webb, R. Clinton, Caldwell, Ruth B., Caldwell, R. William
Format: Artigo
Jezik:Inglês
Izdano: 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2996466/
https://ncbi.nlm.nih.gov/pubmed/20807329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1743-6109.2010.01996.x
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