Grp78 Heterozygosity Regulates Chaperone Balance in Exocrine Pancreas with Differential Response to Cerulein-Induced Acute Pancreatitis

The endoplasmic reticulum (ER) is abundant in the acinar cells of the exocrine pancreas. To test the role of ER homeostasis in acute pancreatitis, we manipulated GRP78 levels, a major ER chaperone, in mice. Grp78(+/+) and (+/−) littermates were fed either a regular diet (RD) or a high-fat diet. Acin...

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Autors principals: Ye, Risheng, Mareninova, Olga A., Barron, Ernesto, Wang, Miao, Hinton, David R., Pandol, Stephen J., Lee, Amy S.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Investigative Pathology 2010
Matèries:
Regular Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2993313/
https://ncbi.nlm.nih.gov/pubmed/20971738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.100368
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