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In vivo efficacy of a chitosan/IL-12 adjuvant system for protein-based vaccines

Vaccines based on recombinant proteins require adjuvant systems in order to generate Th1-type immune responses. We have developed a vaccine adjuvant system using a viscous chitosan solution and interleukin (IL)-12, a Th1-inducing cytokine. The chitosan solution is designed to create a depot of antig...

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Autori principali: Heffernan, Michael J., Zaharoff, David A., Fallon, Jonathan K., Schlom, Jeffrey, Greiner, John W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2992965/
https://ncbi.nlm.nih.gov/pubmed/20965561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2010.09.058
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