Conditional Gene Targeting in Mouse Pancreatic β-Cells: Analysis of Ectopic Cre Transgene Expression in the Brain

OBJECTIVE: Conditional gene targeting has been extensively used for in vivo analysis of gene function in β-cell biology. The objective of this study was to examine whether mouse transgenic Cre lines, used to mediate β-cell– or pancreas-specific recombination, also drive Cre expression in the brain....

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Auteurs principaux: Wicksteed, Barton, Brissova, Marcela, Yan, Wenbo, Opland, Darren M., Plank, Jennifer L., Reinert, Rachel B., Dickson, Lorna M., Tamarina, Natalia A., Philipson, Louis H., Shostak, Alena, Bernal-Mizrachi, Ernesto, Elghazi, Lynda, Roe, Michael W., Labosky, Patricia A., Myers, Martin G., Gannon, Maureen, Powers, Alvin C., Dempsey, Peter J.
Format: Artigo
Langue:Inglês
Publié: American Diabetes Association 2010
Sujets:
Islet Studies
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2992770/
https://ncbi.nlm.nih.gov/pubmed/20802254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-0624
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