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An Assessment of Chemoselective Neoglycosylation Methods Using Chlorambucil as a Model

To systematically assess the impact of glycosylation and the corresponding chemoselective linker upon the anticancer activity/selectivity of the drug chlorambucil, herein we report the synthesis and anticancer activities of a 63-member library of chlorambucil-based neoglycosides. A comparison of N-a...

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Detalhes bibliográficos
Main Authors: Goff, Randal D., Thorson, Jon S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2988911/
https://ncbi.nlm.nih.gov/pubmed/20973561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm101024j
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