Hypoxia-dependent sequestration of an oxygen sensor by a widespread structural motif can shape the hypoxic response - a predictive kinetic model

BACKGROUND: The activity of the heterodimeric transcription factor hypoxia inducible factor (HIF) is regulated by the post-translational, oxygen-dependent hydroxylation of its α-subunit by members of the prolyl hydroxylase domain (PHD or EGLN)-family and by factor inhibiting HIF (FIH). PHD-dependent...

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Detaylı Bibliyografya
Asıl Yazarlar: Schmierer, Bernhard, Novák, Béla, Schofield, Christopher J
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2010
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2984394/
https://ncbi.nlm.nih.gov/pubmed/20955552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1752-0509-4-139
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