Activation of MYC in a masked t(8;17) translocation results in an aggressive B-cell leukemia.

We have analyzed the oncogene rearrangements involving BCL2 and MYC in the leukemia cells of a patient with an aggressive prolymphocytic leukemia that had an abnormal karyotype including a t(14;18) translocation and a chromosome 17q+. Molecular analysis showed that BCL2 was rearranged in the major b...

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Bibliographic Details
Main Authors: Gauwerky, C E, Huebner, K, Isobe, M, Nowell, P C, Croce, C M
Format: Artigo
Language:Inglês
Published: 1989
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC298391/
https://ncbi.nlm.nih.gov/pubmed/2682663
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