Necessity of inositol (1,4,5)-trisphosphate receptor 1 and µ-calpain in NO-induced osteoclast motility

In skeletal remodeling, osteoclasts degrade bone, detach and move to new locations. Mechanical stretch and estrogen regulate osteoclast motility via nitric oxide (NO). We have found previously that NO stimulates guanylyl cyclase, activating the cGMP-dependent protein kinase 1 (PKG1), reversibly term...

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Hlavní autoři: Yaroslavskiy, Beatrice B., Sharrow, Allison C., Wells, Alan, Robinson, Lisa J., Blair, Harry C.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2007
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2976040/
https://ncbi.nlm.nih.gov/pubmed/17690304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.004184
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