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Evolution of a Signaling Nexus Constrained by Protein Interfaces and Conformational States
Heterotrimeric G proteins act as the physical nexus between numerous receptors that respond to extracellular signals and proteins that drive the cytoplasmic response. The Gα subunit of the G protein, in particular, is highly constrained due to its many interactions with proteins that control or reac...
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| Main Authors: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Public Library of Science
2010
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2954821/ https://ncbi.nlm.nih.gov/pubmed/20976244 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1000962 |
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