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Genipin-Induced Inhibition of Uncoupling Protein-2 Sensitizes Drug-Resistant Cancer Cells to Cytotoxic Agents

Uncoupling protein-2 (UCP2) is known to suppress mitochondrial reactive oxygen species (ROS) production and is employed by drug-resistant cancer cells to mitigate oxidative stress. Using the drug-sensitive HL-60 cells and the drug-resistant MX2 subline as model systems, we show that genipin, a UCP2...

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Autori principali: Mailloux, Ryan J., Adjeitey, Cyril Nii-Klu, Harper, Mary-Ellen
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2953501/
https://ncbi.nlm.nih.gov/pubmed/20967268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0013289
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