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Including Receptor Flexibility and Induced Fit Effects into the Design of MMP-2 Inhibitors
Matrix metalloproteinases (MMPs) comprise a class of flexible proteins required for normal tissue remodeling. Overexpression of MMPs is associated with a wide range of pathophysiological processes, including vascular disease, multiple sclerosis, Alzheimer’s disease, and cancer. Nearly all MMP inhibi...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2950069/ https://ncbi.nlm.nih.gov/pubmed/19882751 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jmr.989 |
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