SATB2 augments ΔNp63α in head and neck squamous cell carcinoma

ΔNp63α is a critical pro-survival protein overexpressed in 80% of head and neck squamous cell carcinomas (HNSCCs) where it inhibits TAp73β transcription of p53-family target genes, which is thought to increase HNSCC resistance to chemotherapy-induced cell death. However, the mechanisms governing ΔNp...

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Autors principals: Chung, Jacky, Lau, Joanne, Cheng, Lynn S, Grant, R Ian, Robinson, Fiona, Ketela, Troy, Reis, Patricia P, Roche, Olga, Kamel-Reid, Suzanne, Moffat, Jason, Ohh, Michael, Perez-Ordonez, Bayardo, Kaplan, David R, Irwin, Meredith S
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2010
Matèries:
Scientific Reports
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2948183/
https://ncbi.nlm.nih.gov/pubmed/20829881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2010.125
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