IL-10 inhibits transcription elongation of the human TNF gene in primary macrophages

IL-10 plays a central nonredundant role in limiting inflammation in vivo. However, the mechanisms involved remain to be resolved. Using primary human macrophages, we found that IL-10 inhibits selected inflammatory genes, primarily at a level of transcription. At the TNF gene, this occurs not through...

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Bibliografiske detaljer
Main Authors: Smallie, Tim, Ricchetti, Giuseppe, Horwood, Nicole J., Feldmann, Marc, Clark, Andrew R., Williams, Lynn M.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2010
Fag:
Brief Definitive Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2947066/
https://ncbi.nlm.nih.gov/pubmed/20805562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20100414
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