Effects of the EGFR Inhibitor Erlotinib on Magnesium Handling

A mutation in pro-EGF causes isolated hypomagnesemia, and monoclonal antibodies targeting the extracellular domain of the EGF receptor (EGFR) affect epithelial Mg(2+) transport. The effect of the EGFR tyrosine kinase inhibitor erlotinib on Mg(2+) homeostasis, however, remains unknown. Here, we injec...

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Autors principals: Dimke, Henrik, van der Wijst, Jenny, Alexander, Todd R., Meijer, Inez M.J., Mulder, Gemma M., van Goor, Harry, Tejpar, Sabine, Hoenderop, Joost G., Bindels, René J.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Nephrology 2010
Matèries:
Basic Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2938592/
https://ncbi.nlm.nih.gov/pubmed/20595681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2009111153
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