TNFα and IFNγ Synergistically Enhance Transcriptional Activation of CXCL10 in Human Airway Smooth Muscle Cells via STAT-1, NF-κB, and the Transcriptional Coactivator CREB-binding Protein

Asthmatic airway smooth muscle (ASM) expresses interferon-γ-inducible protein-10 (CXCL10), a chemokine known to mediate mast cell migration into ASM bundles that has been reported in the airways of asthmatic patients. CXCL10 is elevated in patients suffering from viral exacerbations of asthma and in...

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מידע ביבליוגרפי
Main Authors: Clarke, Deborah L., Clifford, Rachel L., Jindarat, Sarawut, Proud, David, Pang, Linhua, Belvisi, Maria, Knox, Alan J.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2010
נושאים:
Signal Transduction
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937941/
https://ncbi.nlm.nih.gov/pubmed/20833730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.0999952
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