Notch1 Is Required for Maintenance of the Reservoir of Adult Hippocampal Stem Cells

Notch1 regulates neural stem cell (NSC) number during development, but its role in adult neurogenesis is unclear. We generated nestin-CreER(T2)/R26R-YFP/Notch1(loxP/loxP) [Notch1inducible knock-out (iKO)] mice to allow tamoxifen (TAM)-inducible elimination of Notch1 and concomitant expression of yel...

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Main Authors: Ables, Jessica L., DeCarolis, Nathan A., Johnson, Madeleine A., Rivera, Phillip D., Gao, Zhengliang, Cooper, Don C., Radtke, Freddy, Hsieh, Jenny, Eisch, Amelia J.
Formato: Artigo
Idioma:Inglês
Publicado: Society for Neuroscience 2010
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2935844/
https://ncbi.nlm.nih.gov/pubmed/20685991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4721-09.2010
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