A PPARα Promoter Variant Impairs ERR-Dependent Transactivation and Decreases Mortality after Acute Coronary Ischemia in Patients with Diabetes

Activation of peroxisome proliferator-activated receptor alpha (PPARα) occurs in animal models of diabetes (DM) and is implicated in pathological responses to myocardial ischemia. Using bioinformatics, we identified a single nucleotide polymorphism (SNP) in the PPARα gene promoter (PPARA −54,642 G&g...

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Détails bibliographiques
Auteurs principaux: Cresci, Sharon, Huss, Janice M., Beitelshees, Amber L., Jones, Philip G., Minton, Matt R., Dorn, Gerald W., Kelly, Daniel P., Spertus, John A., McLeod, Howard L.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2010
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2933242/
https://ncbi.nlm.nih.gov/pubmed/20838448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012584
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