High-throughput proteomic analysis of formalin-fixed paraffin-embedded tissue microarrays using MALDI imaging mass spectrometry

A novel method for high-throughput proteomic analysis of formalin-fixed paraffin-embedded (FFPE) tissue microarrays (TMA) is described using on-tissue tryptic digestion followed by MALDI imaging MS. A TMA section containing 112 needle core biopsies from lung-tumor patients was analyzed using MS and...

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Autores principales: Groseclose, M. Reid, Massion, Pierre P., Chaurand, Pierre, Caprioli, Richard M.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2927989/
https://ncbi.nlm.nih.gov/pubmed/18712763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pmic.200800495
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