A genetically modulated, intrinsic cingulate circuit supports human nicotine addiction

Whole-genome searches have identified nicotinic acetylcholine receptor α5-α3-β4 subunit gene variants that are associated with smoking. How genes support this addictive and high-risk behavior through their expression in the brain remains poorly understood. Here we show that a key α5 gene variant Asp...

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Autors principals: Hong, L. Elliot, Hodgkinson, Colin A., Yang, Yihong, Sampath, Hemalatha, Ross, Thomas J., Buchholz, Brittany, Salmeron, Betty Jo, Srivastava, Vibhuti, Thaker, Gunvant K., Goldman, David, Stein, Elliot A.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2010
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2922167/
https://ncbi.nlm.nih.gov/pubmed/20643934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1004745107
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