Phosphatidylinositol-4,5-Bisphosphate (PIP(2)) Stabilizes the Open Pore Conformation of the Kv11.1 (hERG) Channel

Phosphatidylinositol-4,5-bisphosphate (PIP(2)) is a phospholipid that has been shown to modulate several ion channels, including some voltage-gated channels like Kv11.1 (hERG). From a biophysical perspective, the mechanisms underlying this regulation are not well characterized. From a physiological...

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Autori principali: Rodriguez, Nicolas, Amarouch, Mohamed Yassine, Montnach, Jérôme, Piron, Julien, Labro, Alain J., Charpentier, Flavien, Mérot, Jean, Baró, Isabelle, Loussouarn, Gildas
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Biophysical Society 2010
Soggetti:
Channels and Transporters
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2920645/
https://ncbi.nlm.nih.gov/pubmed/20712994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.06.013
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