Factor Xa induces tissue factor expression in endothelial cells by P44/42 MAPK and NF-κB-dependent pathways

BACKGROUND: Tissue factor (TF) is an initiator of coagulation. The serine protease factor Xa (FXa) is the convergence point of the extrinsic and intrinsic components of the coagulation cascade. In addition to its hemostatic function, FXa elicits inflammatory responses in endothelial cells that may b...

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Autores principales: Jiang, Rong, Wang, Ning-Ping, Tanaka, Kenichi A., Levy, Jerrold H., Guyton, Robert A., Zhao, Zhi-Qing, Vinten-Johansen, Jakob
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2920361/
https://ncbi.nlm.nih.gov/pubmed/20451919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jss.2010.01.041
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