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Altered structural fluctuations in duplex RNA versus DNA: a conformational switch involving base pair opening

DNA and RNA are known to have different structural properties. In the present study, molecular dynamics (MD) simulations on a series of RNA and DNA duplexes indicate differential structural flexibility for the two classes of oligonucleotides. In duplex RNA, multiple base pairs experienced local open...

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Bibliographic Details
Main Authors: Pan, Yongping, MacKerell, Alexander D.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2003
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC291876/
https://ncbi.nlm.nih.gov/pubmed/14654688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkg941
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