The Acyl-Coenzyme A:Cholesterol Acyltransferase Inhibitor CI-1011 Reverses Diffuse Brain Amyloid Pathology in Aged Amyloid Precursor Protein Transgenic Mice

Cerebral accumulation of amyloid β-peptide (Aβ) is characteristic of Alzheimer disease and of amyloid precursor protein (APP) transgenic mice. Here, we assessed the efficacy of CI-1011, an inhibitor of acyl-coenzyme A:cholesterol acyltransferase, which is suitable for clinical use, in reducing amylo...

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Auteurs principaux: Huttunen, Henri J., Havas, Daniel, Peach, Camilla, Barren, Cory, Duller, Stephan, Xia, Weiming, Frosch, Matthew P., Hutter-Paier, Birgit, Windisch, Manfred, Kovacs, Dora M.
Format: Artigo
Langue:Inglês
Publié: 2010
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2918281/
https://ncbi.nlm.nih.gov/pubmed/20613640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/NEN.0b013e3181e77ed9
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