PAC1 Gene Knockout Reveals an Essential Role of Chaperone-Mediated 20S Proteasome Biogenesis and Latent 20S Proteasomes in Cellular Homeostasis

The 26S proteasome, a central enzyme for ubiquitin-dependent proteolysis, is a highly complex structure comprising 33 distinct subunits. Recent studies have revealed multiple dedicated chaperones involved in proteasome assembly both in yeast and in mammals. However, none of these chaperones is essen...

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Bibliographic Details
Main Authors: Sasaki, Katsuhiro, Hamazaki, Jun, Koike, Masato, Hirano, Yuko, Komatsu, Masaaki, Uchiyama, Yasuo, Tanaka, Keiji, Murata, Shigeo
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2010
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2916404/
https://ncbi.nlm.nih.gov/pubmed/20498273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00216-10
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