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Aminoglycoside activity observed on single pre-translocation ribosome complexes
Aminoglycoside-class antibiotics bind directly to ribosomal RNA, imparting pleiotropic effects on ribosome function. Despite in-depth structural investigations of aminoglycoside–RNA oligonucleotide and aminoglycoside-ribosome interactions, mechanisms explaining the unique ribosome inhibition profile...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2914512/ https://ncbi.nlm.nih.gov/pubmed/19946275 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.274 |
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