6-thioguanine selectively kills BRCA2 defective tumours and overcomes PARP inhibitor resistance

Familial breast and ovarian cancers are often defective in homologous recombination (HR) due to mutations in the BRCA1 or BRCA2 genes. Cisplatin chemotherapy or poly(ADP-ribose) polymerase (PARP) inhibitors are tested for these tumours in clinical trials. In a screen for novel drugs that selectively...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Glavni autori: Issaeva, Natalia, Thomas, Huw D., Djurenovic, Tatjana, Jaspers, Janneke E., Stoimenov, Ivaylo, Kyle, Suzanne, Pedley, Nicholas, Gottipati, Ponnari, Zur, Rafal, Sleeth, Kate, Chatzakos, Vicky, Mulligan, Evan, Lundin, Cecilia, Gubanova, Evgenia, Kersbergen, Ariena, Harris, Adrian L, Sharma, Ricky A, Rottenberg, Sven, Curtin, Nicola J., Helleday, Thomas
Format: Artigo
Jezik:Inglês
Izdano: 2010
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2913123/
https://ncbi.nlm.nih.gov/pubmed/20631063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-3416
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items