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Identification of Novel Synthetic Toll-like Receptor 2 Agonists by High Throughput Screening

Toll-like receptors (TLRs) play a central role in host defense by inducing inflammatory and adaptive immune responses following infection. Drugs that target TLRs are of considerable interest as potential inflammatory regulators, vaccine adjuvants, and novel immunotherapeutics. TLR2, in cooperation w...

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Detalhes bibliográficos
Main Authors: Guan, Yue, Omueti-Ayoade, Katherine, Mutha, Sarita K., Hergenrother, Paul J., Tapping, Richard I.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2911294/
https://ncbi.nlm.nih.gov/pubmed/20504771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.116046
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