Vaccination with synthetic analog peptides derived from WT1 oncoprotein induces T-cell responses in patients with complete remission from acute myeloid leukemia

A pilot study was undertaken to assess the safety, activity, and immunogenicity of a polyvalent Wilms tumor gene 1 (WT1) peptide vaccine in patients with acute myeloid leukemia in complete remission but with molecular evidence of WT1 transcript. Patients received 6 vaccinations with 4 WT1 peptides (...

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Autors principals: Maslak, Peter G., Dao, Tao, Krug, Lee M., Chanel, Suzanne, Korontsvit, Tatyana, Zakhaleva, Victoria, Zhang, Ronghua, Wolchok, Jedd D., Yuan, Jianda, Pinilla-Ibarz, Javier, Berman, Ellin, Weiss, Mark, Jurcic, Joseph, Frattini, Mark G., Scheinberg, David A.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2010
Matèries:
Clinical Trials and Observations
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2910606/
https://ncbi.nlm.nih.gov/pubmed/20400682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-10-250993
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