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Bevacizumab-Induced Tumor Vessel Remodeling in Rhabdomyosarcoma Xenografts Increases the Effectiveness of Adjuvant Ionizing Radiation

PURPOSE: Inhibition of VEGF may effect transient “normalization” of tumor vasculature by pruning immature vessels, resulting in improved tumor perfusion and oxygenation. This may improve the efficacy of adjuvant ionizing radiation (IR). We tested this hypothesis using bevacizumab, an anti-VEGF antib...

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Détails bibliographiques
Auteurs principaux: Myers, Adrianne L., Williams, Regan F., Ng, Cathy Y., Hartwich, Joseph E., Davidoff, Andrew M.
Format: Artigo
Langue:Inglês
Publié: 2010
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2904306/
https://ncbi.nlm.nih.gov/pubmed/20620299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpedsurg.2010.02.068
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