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Bevacizumab-Induced Tumor Vessel Remodeling in Rhabdomyosarcoma Xenografts Increases the Effectiveness of Adjuvant Ionizing Radiation
PURPOSE: Inhibition of VEGF may effect transient “normalization” of tumor vasculature by pruning immature vessels, resulting in improved tumor perfusion and oxygenation. This may improve the efficacy of adjuvant ionizing radiation (IR). We tested this hypothesis using bevacizumab, an anti-VEGF antib...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2904306/ https://ncbi.nlm.nih.gov/pubmed/20620299 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpedsurg.2010.02.068 |
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