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The Role of Glutamic or Aspartic Acid in Position Four of the Epitope Binding Motif and Thyrotropin Receptor-Extracellular Domain Epitope Selection in Graves' Disease

Context: Development of Graves' disease (GD) is related to HLA-DRB1*0301 (DR3),and more specifically to arginine at position 74 of the DRB1 molecule. The extracellular domain (ECD) of human TSH receptor (hTSH-R) contains the target antigen. Objective and Design: We analyzed the relation between...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Inaba, Hidefumi, Martin, William, Ardito, Matt, De Groot, Anne Searls, De Groot, Leslie J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Endocrine Society 2010
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2902065/
https://ncbi.nlm.nih.gov/pubmed/20392871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2009-2393
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