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Side-chain Pairing Preferences in the Parallel Coiled-coil Dimer Motif: Insight on Ion-pairing between Core and Flanking Sites

A new strategy for rapid evaluation of sequence-stability relationships in the parallel coiled-coil motif is described. The experimental design relies upon thiol-thioester exchange equilibria, an approach that is particularly well suited to examination of heterodimeric systems. Our model system has...

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Détails bibliographiques
Auteurs principaux: Steinkruger, Jay D., Woolfson, Derek N., Gellman, Samuel H.
Format: Artigo
Langue:Inglês
Publié: 2010
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2898205/
https://ncbi.nlm.nih.gov/pubmed/20465308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja100080q
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