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THROMBIN REGULATES METASTATIC POTENTIAL OF HUMAN RHABDOMYOSARCOMA CELLS – DISTINCT ROLE OF PAR1 AND PAR3 SIGNALING
We observed that human rhabdomyosarcoma (RMS) cells highly express a tissue factor (TF) that promotes thrombin formation, which indirectly and directly affects RMS progression. First, we found that thrombin activates platelets to generate microvesicles (PMVs), which transfer to RMS cells’ α2β3 integ...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2896479/ https://ncbi.nlm.nih.gov/pubmed/20442298 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-10-0019 |
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