Extracellular β-nicotinamide adenine dinucleotide (β-NAD) promotes the endothelial cell barrier integrity via PKA- and EPAC1/Rac1-dependent actin cytoskeleton rearrangement

Extracellular β-NAD is known to elevate intracellular levels of calcium ions, inositol 1,4,5-trisphate and cAMP. Recently, β-NAD was identified as an agonist for P2Y1 and P2Y11 purinergic receptors. Since β-NAD can be released extracellularly from endothelial cells (EC), we have proposed its involve...

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Bibliografski detalji
Glavni autori: Umapathy, Nagavedi S., Zemskov, Evgeny A., Gonzales, Joyce, Gorshkov, Boris A., Sridhar, Supriya, Chakraborty, Trinad, Lucas, Rudolf, Verin, Alexander D.
Format: Artigo
Jezik:Inglês
Izdano: 2010
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2893378/
https://ncbi.nlm.nih.gov/pubmed/20054824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.22029
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